Two Adult Cases of Clear Cell Sarcoma of Kidney / 대한비뇨기과학회지

Clear cell sarcoma of kidney is highly malignant tumor that tends to occur in young infants, and has a tendency to metastasize to the bone. Our review of the literature disclosed 8 cases as to adults with clear cell sarcoma of kidney until December 1995. There was no report about it in the Republic of Korea. We report two adult patients, a young man and a young woman, who had a clear cell sarcoma of kidney.

The Effect of Alpha1-blockers according to Histological Compositions in Patients with Benign Prostatic Hyperplasia / 대한비뇨기과학회지

PURPOSE: Benign prostatic hyperplasia(BPH) describes a hyperplastic process of the stromal and epithelial elements of the prostate. The proliferative rates of each compartment in BPH may vary individually and the prostate is topographically not affected in a uniform way. The proposed mechanism of alphas-blockers in the treatment of BPH is the decrease of prostatic urethral resistance by relaxing the prostatic smooth muscle component present in the stroma. The purpose of this study is to search the effect of alphas-blockers according to histologic compositions in patients with BPH. MATERIALS AND METHODS: From January 1994 to June 1997, 74 patients were treated with alpha1-blockers(> or =1month) before prostatectomy. Of 74 patients, the international prostate symptom score(IPSS) was used in 62 patients to evaluate the severity of voiding difficulties. The clinical response to alpha1-blockers was based upon change in IPSS during medication period. According to histological compositions of prostatectomy specimen, the patients were classified into three groups: predominantly stromal type(20 patients), predominantly glandular type(21 patients) and mixed type(21 patients). RESULTS: There were 17 patients In response group and 45 patients in nonresponse group. The stromal type, glandular type and mixed type were composed of 52.9%, 17.7% and 29.4% respectively in response group and 24.4%, 40.1% and 35.5% respectively in nonresponse group. There was not statistical significant differences between clinical response of the alpha1-blockers and histologic compositions in patients with BPH(p>0.05). CONCLUSIONS: Although stromal type was predominant in response group and glandular type was predominant in nonresponse group, the relationship between the effects of alpha1-blockers and histologic compositions in patients with BPH was not statistically significant. Further evaluation will be necessary to assess the association between effects of alpha1-blockers and histologic difference of prostate in patients with BPH.

Fifteen Cases of Testicular Microlithiasis / 대한비뇨기과학회지

PURPOSE: This study was made to evaluate the clinical characteristics of testicular microlithiasis which shows small diffuse hyperechoic nonshadowing foci throughout both testes on sonography. MATERIALS AND METHODS: Between July 1995 and May 1997, we had seen 15 Patients with dilateral diffuse microlithiasis of the testes on the sonography. Medical records were reviewed with respect to age at presentation, associated diseases, and sonographic and pathologic characteristics. RESULTS: The age of the patients ranged from 8 to 69 years. The testicular microlithiasis was coincidental to the presence of erectile dysfunction(n=5), epididymitis(n=5), varicocele(n=4), epididymal cyst(n=2), infertility(n=1), testicular teratoma(n=1) and diabetes mellitus(n=1). There were considerable variations in the numbers of echogenic foci on each sonography that examined the entire half of the scrotum(from 15 to more than 60 foci). The histological examinations were done in two patients and sbowed the lumina of seminiferous tubules filled with concentrically lamellated calcified concretions. CONCLUSIONS: The testicular microlithiasis showed a wide range of age at presentation and associated with diabetes mellitus and a variety of urological problems including erectile dysfunction, epididymitis, varicoce18, epididymal cyst, infertility and testicular teratoma. The clinical relevance remains unclear at this time. Further additional cases as well as a long-term follow-up would be necessary to assess the association between testicular microlithiasis and these coincidental conditions.

A case of Mixed Gonadal Dysgenesis Managed in Newborn Period / 대한비뇨기과학회지

The authors have experienced a case of mixed gonadal dysgenesis who had a testis on the left side and a streak gonad on the right side with a karyotype of 45,XO/46,XY mosaicism. Bilateral gonadectomy and feminizing genitoplasty were performed for this neonate.